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“Molecular and Nano Probes for Imaging”
Dr. Anatoliy V. Popov
April 13, 2017 @ 11:00 am
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Dr. Anatoliy Popov is the Research Assistant Professor, University of Pennsylvania, Department of Radiology.
Molecular Imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems.
From narrow organic chemist’s point of view Molecular Imaging is design and synthesis of contrast agents and their delivery systems. This can include development of new targeting and/or activatable bioconjugate molecules and nanoparticles.
We have been working on development of the probes that represent all five above categories. We use optical methods, PET and nuclear magnetic resonance in our studies. We have demonstrated the ability to image pH using selective bandwidth quenching of Cerenkov-specific contrast agents. Designed, synthesized and positively tested 1 molecular probe for choline kinase inhibition imaging, 2 molecular probes to MRI bacteremia. Folate modified LDLs target ovarian cancer FR+ cell line. Metal-His6 bonding was successfully applied to construct micelles and nanoemulsion for targeted imaging the lipid-based micelles target and image T-cells. The perfluorocarbon-based nanoemulsion shows promising results for multimodal imaging of ovarian cancer vasculature. Near Infrared PC-PLC sensitive probe was prepared and tested in vitro and in vivo. Near Infrared PLA2- sensitive probes were synthesized and demonstrated a better selectivity than commercially available analogs.
The Molecular Imaging Probes can be broken down into five categories:
• Unspecific or Passively Distributed Probes • Targeted Agents • Nanoparticles • Multimodal Agents • “Smart” or Activatable Probes.